7882/5 | Tocris Bioscience 7882/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7882/5

catalog :

7882/5

quantity :

5 mg

price :

315 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective HDAC4 Degrader (PROTAC )

product information

master code :

7882

SKU :

7882/5

product name :

HDAC4 CHDI Degrader 11

unit size :

5 mg

description :

Potent and selective HDAC4 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1075.26

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC ) (DC50 values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntington s disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC50 = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines. . HDAC4 antibody validated for Simple Western (automated Western) instruments also available: Catalog # NBP2-22151 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent and selective HDAC4 Degrader (PROTAC )

extended description :

Potent and selective HDAC4 Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C52H73F3N8O11S

formula text :

C52H73F3N8O11S

cas num :

3035189-46-6

USD :

315 USD

product details :

Potent and selective HDAC4 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage