7881/10 | Tocris Bioscience 7881/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7881/10

catalog :

7881/10

quantity :

10 mg

price :

255 USD

more info or order :

Tocris Bioscience product webpage

product information

master code :

7881

SKU :

7881/10

product name :

CHDI 00580985

unit size :

10 mg

description :

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

target :

Rho-kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

372.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CHDI 00580985 is a potent and selective ROCK inhibitor (IC50 values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC50 = 4 nM). In vivo , CHDI 00580985 reduces ROCK signaling in Huntington s disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.

top caption :

Potent and selective ROCK2 inhibitor; orally bioavailable and brain penetrant

extended description :

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

chemical name text :

(2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide

formula :

C20H25FN4O2

formula text :

C20H25FN4O2

cas num :

2573071-18-6

USD :

255 USD

product details :

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage