7878/10 | Tocris Bioscience 7878/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7878/10

catalog :

7878/10

quantity :

10 mg (also 50 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zhang Y, Mun S, Linares J, Ahn J, Towers C, Ji C, et al. ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun. 2018;9:4373 pubmed publisher

image

image 1 :

Inducer of autophagy via interaction of p62 and LC3

product information

master code :

7878

SKU :

7878/10

product name :

XIE62-1004

unit size :

10 mg (also 50 mg)

description :

Inducer of autophagy via interaction of p62 and LC3

target :

p62/SQSTM1

category :

Small Molecules

purity :

98%

observed molecular weight :

399.91

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro . Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

top caption :

Inducer of autophagy via interaction of p62 and LC3

extended description :

Inducer of autophagy via interaction of p62 and LC3

chemical name text :

2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride

formula :

C23H25NO3.HCl

formula text :

C23H25NO3.HCl

cas num :

2421146-32-7

USD :

154 USD

product details :

Inducer of autophagy via interaction of p62 and LC3

alt names :

A170, Autophagy Receptor P62, DMRV, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, FTDALS3, NADGP, ORCA, OSIL, oxidative stress induced like, p60PDB3, p62, p62B, Paget disease of bone 3, PDB3, phosphotyrosine independent ligand for the Lck SH2 domain p62, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, sequestosome 1, sequestosome-1, SQSTM1, Ubiquitin-binding protein p62, ZIP3

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage