XIE62-1004 | Tocris Bioscience 7878/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

XIE62-1004

catalog :

7878/10

quantity :

10 mg (also 50 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zhang Y, Mun S, Linares J, Ahn J, Towers C, Ji C, et al. ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun. 2018;9:4373 pubmed publisher

image

image 1 :

Inducer of autophagy via interaction of p62 and LC3

product information

brand :

Tocris

catalog number base :

7878

SKU :

7878/10

product name :

XIE62-1004

units size :

10 mg (also 50 mg)

description :

Inducer of autophagy via interaction of p62 and LC3

target :

Autophagy Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

399.91

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro . Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.

top caption :

Inducer of autophagy via interaction of p62 and LC3

extended description :

Inducer of autophagy via interaction of p62 and LC3

chemical name text :

2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride

formula :

C23H25NO3.HCl

formula text :

C23H25NO3.HCl

cas num :

2421146-32-7

USD :

154 USD

product details :

Inducer of autophagy via interaction of p62 and LC3

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage