7865/10 | Tocris Bioscience 7865/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7865/10

catalog :

7865/10

quantity :

10 mg (also 50 mg)

price :

179 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective pan-Aurora kinases inhibitor

product information

master code :

7865

SKU :

7865/10

product name :

AMG 900

unit size :

10 mg (also 50 mg)

description :

Potent pan-Aurora kinase inhibitor

target :

Aurora Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

503.58

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMG 900 is a potent pan-Aurora kinase inhibitor (IC50 values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively). It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38 , Met, and TYK2. AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells. AMG 900 inhibits proliferation of 26 tumor cell lines (EC50 ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat. No. 1097)-resistant tumor cell lines. In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth. It is orally bioavailable.

top caption :

Potent and selective pan-Aurora kinases inhibitor

extended description :

Potent pan-Aurora kinase inhibitor

chemical name text :

N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine

formula :

C28H21N7OS

formula text :

C28H21N7OS

cas num :

945595-80-2

USD :

179 USD

product details :

Potent pan-Aurora kinase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage