7864/10 | Tocris Bioscience 7864/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7864/10

catalog :

7864/10

quantity :

10 mg (also 50 mg)

price :

139 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective TGF- kinase inhibitor

product information

master code :

7864

SKU :

7864/10

product name :

LY 2109761

unit size :

10 mg (also 50 mg)

description :

Selective TGF- kinase inhibitor

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

441.53

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LY 2109761 is a selective dual TGF- receptor type I and II (T RI/II) inhibitor (Ki values are 38 and 300 nM in a cell-free assay, respectively); it inhibits the kinase activity of both TGF- RI and TGF- RII. In vitro , it significantly inhibits the growth, motility, and invasiveness of L3.6pl/GLT pancreatic cancer cells and completely suppresses TGF- -induced Smad2 phosphorylation. In vivo , LY 2109761, in combination with Gemcitabine, significantly reduces tumor volume and spontaneous abdominal metastases in a murine model of metastatic pancreatic cancer. LY 2109761 is orally bioavailable.

top caption :

Selective TGF- kinase inhibitor

extended description :

Selective TGF- kinase inhibitor

chemical name text :

4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline

formula :

C26H27N5O2

formula text :

C26H27N5O2

cas num :

700874-71-1

USD :

139 USD

product details :

Selective TGF- kinase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage