7852/10 | Tocris Bioscience 7852/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7852/10

catalog :

7852/10

quantity :

10 mg

price :

130 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent covalent inhibitor of Cereblon

product information

master code :

7852

SKU :

7852/10

product name :

EM12-SO2F

unit size :

10 mg

description :

Potent covalent inhibitor of Cereblon

target :

CRBN

category :

Small Molecules

purity :

95%

observed molecular weight :

326.3

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

top caption :

Potent covalent inhibitor of Cereblon

extended description :

Potent covalent inhibitor of Cereblon

chemical name text :

2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride

formula :

C13H11FN2O5S

formula text :

C13H11FN2O5S

cas num :

2803819-61-4

USD :

130 USD

product details :

Potent covalent inhibitor of Cereblon

alt names :

cereblon, DKFZp781K0715, MGC27358, MRT2, MRT2A, non-syndromic, autosomal recessive, 2A, protein cereblon, protein x 0001

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage