chemical

7845/10

7845/10

10 mg (also 50 mg)

159 USD

7845/10

AZ1 USP25/28 inhibitor

10 mg (also 50 mg)

Selective USP25 and USP28 inhibitor

USP28

Small Molecules

98%

422.21

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AZ1 USP25/28 inhibitor is a selective inhibitor of USP28 (IC50 = 0.6 M, Kd= 0.2 - 3.7 M) and USP25 (IC50 = 0.7 M). AZ1 USP25/28 inhibitor exhibits selectivity for USP25 and USP28 over other DUB family members. The compound dose-dependently reduces c-Myc levels in colon carcinoma cells in vitro and induces cell death (EC50 values are 18 - 20 M). In a mouse Alzheimer s disease model, AZ1 USP25/28 inhibitor reduces amyloid burden, attenuates microglial activation and improves synaptic and cognitive function.

Selective USP25 and USP28 inhibitor

Selective USP25 and USP28 inhibitor

2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol

C17H16BrF4NO2

C17H16BrF4NO2

2165322-94-9

159 USD

Selective USP25 and USP28 inhibitor

cMyc, Deubiquitinating enzyme 28, EC 3.1.2.15, EC 3.4.19.12, KIAA1515ubiquitin carboxyl-terminal hydrolase 28, Myc, Myc2, Niard, Nird, ubiquitin specific peptidase 28, ubiquitin specific protease 28, ubiquitin thioesterase 28, Ubiquitin Thiolesterase 25, Ubiquitin thiolesterase 28, Ubiquitin-specific-processing protease 28

Store at -20░C