7842/5 | Tocris Bioscience 7842/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7842/5

catalog :

7842/5

quantity :

5 mg

price :

371 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC )

product information

master code :

7842

SKU :

7842/5

product name :

NAMPT PROTAC A7

unit size :

5 mg

description :

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1185.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NAMPT PROTAC A7 is a potent and selective intracellular nicotinamide phosphoribosyl transferase (iNAMPT) Degrader (PROTAC ) (IC50 of 9.5 nM against the enzymatic activity of NAMPT). Comprises a potent NAMPT inhibitor joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. Proteomic analysis of global protein level changes confirms selectivity. NAMPT PROTAC A7 decreases iNAMPT level and the secretion of extracellular NAMPT (eNAMPT) in CT26 or MC38 cells. In CT26 tumor bearing BALB/c mice, the compound degrades tumoral NAMPT, and boosts antitumor immunity by inhibiting tumor infiltrating myeloid-derived suppressive cells. . Antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF4335 and MAB40441 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC )

extended description :

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-ca

formula :

C58H76N10O11S3

formula text :

C58H76N10O11S3

cas num :

2484876-94-8

USD :

371 USD

product details :

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage