7837/5 | Tocris Bioscience 7837/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7837/5

catalog :

7837/5

quantity :

5 mg

price :

386 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

JB 300 AURORA-A PROTAC Degrader

product information

master code :

7837

SKU :

7837/5

product name :

JB 300

unit size :

5 mg

description :

Aurora A Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

906.38

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JB 300 is a potent and selective Aurora A Degrader (PROTAC DC50 = 30 nM and Dmax = 78%). It comprises a cereblon E3-ligase ligand Thalidomide (Cat. No. 0652) joined by a PEG2 linker to the Aurora A inhibitor MK-5108. The compound depletes Aurora A in MV4-11 cell lines and exhibits no degradation of Aurora B at 10 uM. JB 300 shows dose-dependent cytotoxicity in AML cells. . Aurora A antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3295 and NBP1-51843 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Aurora A Degrader (PROTAC )

extended description :

Aurora A Degrader (PROTAC )

chemical name text :

trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide

formula :

C43H45ClFN7O10S

formula text :

C43H45ClFN7O10S

cas num :

3038446-90-8

USD :

386 USD

product details :

Aurora A Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage