chemical

AUNP 12

7831/1

1 mg

205 USD

7831

7831/1

AUNP 12

1 mg

Peptide inhibitor of the PD-1 signaling pathway

Immune Checkpoint Inhibitors

Peptides

95%

3261.56

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AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFN release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

Peptide inhibitor of the PD-1 signaling pathway

Peptide inhibitor of the PD-1 signaling pathway

C142H226N40O48

C142H226N40O48

1353563-85-5

205 USD

Peptide inhibitor of the PD-1 signaling pathway

Store at -20°C