7831/1 | Tocris Bioscience 7831/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7831/1

catalog :

7831/1

quantity :

1 mg

price :

205 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Peptide inhibitor of the PD-1 signaling pathway

product information

master code :

7831

SKU :

7831/1

product name :

AUNP 12

unit size :

1 mg

description :

Peptide inhibitor of the PD-1 signaling pathway

target :

PD-1

category :

Peptides

purity :

95%

observed molecular weight :

3261.56

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFN release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

top caption :

Peptide inhibitor of the PD-1 signaling pathway

extended description :

Peptide inhibitor of the PD-1 signaling pathway

formula :

C142H226N40O48

formula text :

C142H226N40O48

cas num :

1353563-85-5

USD :

205 USD

product details :

Peptide inhibitor of the PD-1 signaling pathway

alt names :

B7-DC, B7H1, B7-H1, Butyrophilin-like Protein, CD273, CD274, CD279, CD279 antigen, hPD-1, IFG, IFI, IFNG, IFNgamma, PD1, PD1hPD-l, PDCD1, PDCD1L1, PDCD1LG1, PDCD1LG2, PDL1, PDL2, programmed cell death 1, programmed cell death protein 1, Protein PD-1, SLEB2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage