7828/5 | Tocris Bioscience 7828/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7828/5

catalog :

7828/5

quantity :

5 mg

price :

349 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

product information

master code :

7828

SKU :

7828/5

product name :

HHP 9

unit size :

5 mg

description :

BET bromodomain Degrader (PROTAC also potent Hedgehog pathway inhibitor

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

900.99

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HHP 9 is a potent BET bromodomain Degrader (PROTAC DC50 values are 0.03 M, 0.2 M and 0.2 M at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9 in vitro (after 27h incubation with 0.5 - 5 M of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 ( HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

extended description :

BET bromodomain Degrader (PROTAC also potent Hedgehog pathway inhibitor

chemical name text :

2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

formula :

C49H52N6O11

formula text :

C49H52N6O11

USD :

349 USD

product details :

BET bromodomain Degrader (PROTAC also potent Hedgehog pathway inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage