7826/10 | Tocris Bioscience 7826/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7826/10

catalog :

7826/10

quantity :

10 mg (also 50 mg)

price :

232 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Sonidegib CAS No. 956697-53-3 Potent Smoothened receptor antagonist

product information

master code :

7826

SKU :

7826/10

product name :

Sonidegib

unit size :

10 mg (also 50 mg)

description :

Potent Smoothened receptor antagonist

target :

Smoothened

category :

Small Molecules

purity :

98%

observed molecular weight :

485.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

top caption :

Potent Smoothened receptor antagonist

extended description :

Potent Smoothened receptor antagonist

chemical name text :

rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4 -(trifluoromethoxy)[1,1 -biphenyl]-3-carboxamide

formula :

C26H26F3N3O3

formula text :

C26H26F3N3O3

cas num :

956697-53-3

USD :

232 USD

product details :

Potent Smoothened receptor antagonist

alt names :

bnb, CRJS, FZD11, Gx, Protein Gx, SMO, SMOH, SMOHseven transmembrane helix receptor, smoothened (Drosophila) homolog, smoothened homolog, smoothened homolog (Drosophila)

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage