7825/10 | Tocris Bioscience 7825/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7825/10

catalog :

7825/10

quantity :

10 mg (also 50 mg)

price :

187 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

AZD 7648 CAS No. 2230820-11-6 DNA-PK inhibitor

product information

master code :

7825

SKU :

7825/10

product name :

AZD 7648

unit size :

10 mg (also 50 mg)

description :

Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency

target :

DNA-dependent Protein Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

380.41

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3K , PI3K , PI3K , ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable. AZD 7648 also enhances CRISPR-mediated HDR efficiency.

top caption :

Potent and selective DNA-PK inhibitor

extended description :

Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency

chemical name text :

7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one

formula :

C18H20N8O2

formula text :

C18H20N8O2

cas num :

2230820-11-6

USD :

187 USD

product details :

Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage