7823/10 | Tocris Bioscience 7823/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7823/10

catalog :

7823/10

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gavine P, Mooney L, Kilgour E, Thomas A, Al Kadhimi K, Beck S, et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012;72:2045-56 pubmed publisher

image

image 1 :

AZD 4547 CAS No. 1035270-39-3 Potent and selective FGFR inhibitor

product information

master code :

7823

SKU :

7823/10

product name :

AZD 4547

unit size :

10 mg (also 50 mg)

description :

Potent and selective FGFR inhibitor

target :

FGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

463.56

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC50 values are 0.2 1.8, and 2.5 nM, respectively). It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR ( 2,900-fold), CDK2 ( 50,000-fold), and p38 ( 50,000-fold). In vitro , it has antiproliferative effects on tumor cell lines with deregulated FGFR expression. In vivo , AZD 4547 exhibits dose-dependent inhibition of tumor growth in an FGFR-driven human tumor xenograft mice model. It suppresses osteoclastogenesis and tumor-induced osteolysis in an orthotopic breast cancer bone metastasis mouse model. AZD 4547 is orally bioavailable.

top caption :

Potent and selective FGFR inhibitor

extended description :

Potent and selective FGFR inhibitor

chemical name text :

rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide

formula :

C26H33N5O3

formula text :

C26H33N5O3

cas num :

1035270-39-3

USD :

223 USD

product details :

Potent and selective FGFR inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage