7820/2 | Tocris Bioscience 7820/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7820/2

catalog :

7820/2

quantity :

2 mg

price :

179 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

product information

master code :

7820

SKU :

7820/2

product name :

CU-76

unit size :

2 mg

description :

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

target :

STING/TMEM173

category :

Small Molecules

purity :

98%

observed molecular weight :

407.12

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 M). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN- in THP-1 cells stimulated with interferon-stimulatory DNA.

top caption :

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

extended description :

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

chemical name text :

Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate

formula :

C11H8F2IN5O2

formula text :

C11H8F2IN5O2

cas num :

2400954-58-5

USD :

179 USD

product details :

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

alt names :

endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, hSTING, IL1 beta, IL-1b, IL1B, IL-1F2, Mediator of IRF3 activation, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, SAVI, Stimulator of interferon genes protein, stimulator of interferon protein, sting, STING-beta, TMEM173, transmembrane protein 173

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage