7818/5 | Tocris Bioscience 7818/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7818/5

catalog :

7818/5

quantity :

5 mg

price :

397 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective focal adhesion kinase (FAK) degrader

product information

master code :

7818

SKU :

7818/5

product name :

GSK 215

unit size :

5 mg

description :

Potent and selective focal adhesion kinase (FAK) Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

985.14

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 215 is a potent and selective focal adhesion kinase (FAK) Degrader (PROTAC DC50 = 1.3 nM, Dmax = 90%). Comprises the FAK inhibitor, PND 1186 (Cat. No. 6891), joined by a linker to a VHL E3 ligase ligand. Kinome binding (KinoBead profiling) shows GSK 215 (at 10 nM) has high selectivity for the FAK kinase domain. GSK 215 inhibits cell proliferation in MCF-7 and A549 cells and suppresses A549 cell motility in a wound scratch model system. In CD1 mice, GSK 215 injection induces rapid and profound degradation of FAK in liver (Dmax = 85% at 18h). . PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent and selective focal adhesion kinase (FAK) degrader

extended description :

Potent and selective focal adhesion kinase (FAK) Degrader (PROTAC )

chemical name text :

(2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

formula :

C50H59F3N10O6S

formula text :

C50H59F3N10O6S

cas num :

2743427-26-9

USD :

397 USD

product details :

Potent and selective focal adhesion kinase (FAK) Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage