7816/5 | Tocris Bioscience 7816/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7816/5

catalog :

7816/5

quantity :

5 mg

price :

215 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Polycomb repressive complex 2 (PRC2) Degrader PROTAC )

product information

master code :

7816

SKU :

7816/5

product name :

UNC 6852

unit size :

5 mg

description :

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

832.98

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC DC50 = 0.79 M). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 M, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 M, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 M, Dmax = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Polycomb repressive complex 2 (PRC2) Degrader PROTAC )

extended description :

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C43H48N10O6S

formula text :

C43H48N10O6S

cas num :

2688842-08-0

USD :

215 USD

product details :

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage