7813/5 | Tocris Bioscience 7813/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7813/5

catalog :

7813/5

quantity :

5 mg

price :

364 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selective HyT-based degrader of the CDK9-cyclin T1 complex

product information

master code :

7813

SKU :

7813/5

product name :

LL-K9-3

unit size :

5 mg

description :

Selective HyT-based degrader of the CDK9-cyclin T1 complex

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

683.94

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC50 values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.

top caption :

Selective HyT-based degrader of the CDK9-cyclin T1 complex

extended description :

Selective HyT-based degrader of the CDK9-cyclin T1 complex

chemical name text :

N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide

formula :

C31H49N5O6S3

formula text :

C31H49N5O6S3

cas num :

2809353-52-2

USD :

364 USD

product details :

Selective HyT-based degrader of the CDK9-cyclin T1 complex

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage