7783/50 | Tocris Bioscience 7783/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7783/50

catalog :

7783/50

quantity :

50 mg

price :

279 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7783 - Upadacitinib C17H19F3N6O CAS No. 1310726-60-3

product information

master code :

7783

SKU :

7783/50

product name :

Upadacitinib

unit size :

50 mg

description :

JAK1-selective inhibitor

target :

Jak1

category :

Small Molecules

purity :

98%

observed molecular weight :

380.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Upadacitinib is a potent and selective JAK1 inhibitor (IC50 = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC50 values are 0.014 M, 0.593 M, 1860 M and 2715 M). In vivo , Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

top caption :

JAK1-selective inhibitor

extended description :

JAK1-selective inhibitor

chemical name text :

(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide

formula :

C17H19F3N6O

formula text :

C17H19F3N6O

cas num :

1310726-60-3

USD :

279 USD

product details :

JAK1-selective inhibitor

alt names :

EC 2.7.10, JAK-1, JAK1Atyrosine-protein kinase JAK1, JAK1B, Janus kinase 1EC 2.7.10.2, JTK3

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage