chemical

7781/1

7781/1

1 mg

345 USD

7781/1

tri-GalNAc-C5-amine

1 mg

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

ASGR1/ASGPR1

Small Molecules

90%

1615.75

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tri-GalNAc-C5-amine is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with an alkylC5 linker and an amine group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy- -D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy- -D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-tr

C67H118N14O31

C67H118N14O31

2098275-86-4

345 USD

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

ASGPR, ASGPR 1, ASGP-R 1, ASGPR1, ASGPR2, asialoglycoprotein receptor 1, CLEC4H1, CLEC4H1ASGPR1, CLEC4H2, C-type lectin domain family 4 member H1, HBXBP, Hepatic lectin H1, HL-1, MHL1, RHL1

Store at -20░C