chemical

beta-GalNAc-PEG4-Azide

7780/25

25 mg

541 USD

7780

7780/25

beta-GalNAc-PEG4-Azide

25 mg

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Degrader Building Blocks

Small Molecules

95%

422.44

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-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, -GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. -GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy- -D-galactopyranoside

C16H30N4O9

C16H30N4O9

879004-92-9

541 USD

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Store at -20°C