7774/10 | Tocris Bioscience 7774/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7774/10

catalog :

7774/10

quantity :

10 mg (also 50 mg)

price :

192 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Inhibitor of VHL; blocks interaction of VHL and HIF-

product information

master code :

7774

SKU :

7774/10

product name :

VH 032

unit size :

10 mg (also 50 mg)

description :

Inhibitor of VHL; blocks interaction of VHL and HIF-

target :

VHL

category :

Small Molecules

purity :

98%

observed molecular weight :

472.6

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VH 032 is an inhibitor of E3 ubiquitin ligase VHL (Kd = 185 nM). Blocks interaction between VHL and HIF- downstream of HIF- hydroxylation, initiating hypoxic response. VH 032 treatment causes dose dependent upregulation of HIF-target genes including CA9, GLUT1 and PHD2 in different cell lines. Cell permeable.

top caption :

Inhibitor of VHL; blocks interaction of VHL and HIF-

extended description :

Inhibitor of VHL; blocks interaction of VHL and HIF-

chemical name text :

(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C24H32N4O4S

formula text :

C24H32N4O4S

cas num :

1448188-62-2

USD :

192 USD

product details :

Inhibitor of VHL; blocks interaction of VHL and HIF-

alt names :

BHLHE78, elongin binding protein, HIF 1A, HIF1 alpha, HIF-1a, HIF1A, HRCA1, MOP1, PASD8, Protein G7, pVHL, RCA1, VHL1, von Hippel-Lindau disease tumor suppressor, von Hippel-Lindau syndrome, von Hippel-Lindau tumor suppressor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage