7762/10 | Tocris Bioscience 7762/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7762/10

catalog :

7762/10

quantity :

10 mg (also 50 mg)

price :

161 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

EED 226 CAS No. 2083627-02-3 EED Inhibitor

product information

master code :

7762

SKU :

7762/10

product name :

EED 226

unit size :

10 mg (also 50 mg)

description :

Potent and selective EED inhibitor

target :

EED

category :

Small Molecules

purity :

98%

observed molecular weight :

369.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro , EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo , it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.

top caption :

Potent and selective EED inhibitor

extended description :

Potent and selective EED inhibitor

chemical name text :

N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine

formula :

C17H15N5O3S

formula text :

C17H15N5O3S

cas num :

2083627-02-3

USD :

161 USD

product details :

Potent and selective EED inhibitor

alt names :

embryonic ectoderm development, HEED, polycomb protein EED, WAIT1, WAIT-1, WD protein associating with integrin cytoplasmic tails 1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage