chemical

7761/10

7761/10

10 mg (also 50 mg)

141 USD

7761/10

Ivosidenib

10 mg (also 50 mg)

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Isocitrate Dehydrogenase 1/IDH1

Small Molecules

98%

582.96

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Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 M. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro .

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

(2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

C28H22ClF3N6O3

C28H22ClF3N6O3

1448347-49-6

141 USD

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Cytosolic NADP-isocitrate dehydrogenase, EC 1.1.1.42, IDCD, IDH, IDH1, IDP, IDPC, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, Oxalosuccinate decarboxylase, PICD

Store at -20░C