Ivosidenib | Tocris Bioscience 7761/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ivosidenib

catalog :

7761/10

quantity :

10 mg (also 50 mg)

price :

141 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Ivosidenib CAS No. 1448347-49-6 Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

product information

brand :

Tocris

catalog number base :

7761

SKU :

7761/10

product name :

Ivosidenib

units size :

10 mg (also 50 mg)

description :

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

target :

Dehydrogenase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

582.96

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 M. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro .

top caption :

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

extended description :

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

chemical name text :

(2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

formula :

C28H22ClF3N6O3

formula text :

C28H22ClF3N6O3

cas num :

1448347-49-6

USD :

141 USD

product details :

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage