7760/10 | Tocris Bioscience 7760/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7760/10

catalog :

7760/10

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Selinexor CAS No. 1393477-72-9 Selective exportin 1 (XPO1/CRM1) inhibitor

product information

master code :

7760

SKU :

7760/10

product name :

Selinexor

unit size :

10 mg (also 50 mg)

description :

Selective exportin 1 (XPO1/CRM1) inhibitor

target :

Antiviral Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

443.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and 1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF- and IL-6.

top caption :

Selective exportin 1 (XPO1/CRM1) inhibitor

extended description :

Selective exportin 1 (XPO1/CRM1) inhibitor

chemical name text :

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

formula :

C17H11F6N7O

formula text :

C17H11F6N7O

cas num :

1393477-72-9

USD :

190 USD

product details :

Selective exportin 1 (XPO1/CRM1) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage