7757/2 | Tocris Bioscience 7757/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7757/2

catalog :

7757/2

quantity :

2 mg

price :

314 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

AZ 13824374 Potent and selective ATAD2 bromodomain inhibitor

product information

master code :

7757

SKU :

7757/2

product name :

AZ 13824374

unit size :

2 mg

description :

Potent and selective ATAD2 bromodomain inhibitor

target :

ATAD2

category :

Small Molecules

purity :

98%

observed molecular weight :

562.69

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZ 13824374 is a potent and selective inhibitor of ATPase family AAA domain-containing protein 2 (ATAD2) bromodomain (pIC50 values are 6.2 and 8.2 in NanoBRET assay and FRET assay, respectively). It is >100-fold selective over a range of epigenetic targets from ROMO scan panel (DiscoveRx Corp.). AZ 13824374 shows cellular target engagement (cellular inhibition pIC50 = 6.9) and antiproliferative activity in a range of breast cancer cell lines.

top caption :

Potent and selective ATAD2 bromodomain inhibitor

extended description :

Potent and selective ATAD2 bromodomain inhibitor

chemical name text :

(1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one

formula :

C30H39FN8O2

formula text :

C30H39FN8O2

cas num :

3040082-19-4

USD :

314 USD

product details :

Potent and selective ATAD2 bromodomain inhibitor

alt names :

AAA nuclear coregulator cancer-associated protein, ANCCA, ANCCAMGC131938, ATPase family AAA domain-containing protein 2, ATPase family, AAA domain containing 2, CT137, DKFZp667N1320, EC 3.6.1.3, MGC142216, MGC29843, MGC5254, PRO2000

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage