7755/10 | Tocris Bioscience 7755/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7755/10

catalog :

7755/10

quantity :

10 mg (also 50 mg)

price :

260 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7755 - Asunaprevir C35H46ClN5O9S CAS No. 630420-16-5

product information

master code :

7755

SKU :

7755/10

product name :

Asunaprevir

unit size :

10 mg (also 50 mg)

description :

Potent hepatitis C virus (HCV) NS3 protease inihibitor

target :

CRISPR Reagents

category :

Small Molecules

purity :

98%

observed molecular weight :

748.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Asunaprevir is a potent HCV NS3 protease inhibitor (IC50 = 0.2-3.5 nM). Asunaprevir can be used to control CRIPSR-Cas9 gene editing via the small molecule-assisted shut-off (SMASh) technique, which involves fusion of Cas9 to a peptide comprising a protease domain and a degron tag. Asuprenavir blocks the protease-mediated removal of the degron tag leading to degradation of Cas9 through proteasome and autophagolysosome pathways. It can also be used as a resversible switch to control CAR (chimeric antigen receptor)-T cells, where the CAR has been modified by insertion of a hepatitis C virus nonstructural protein 3 protease (HCV-NS3) between the scFv and the hinge domains. Also inhibits SARS-CoV-2 Mpro activity (IC50 = 15-48.4 M).

top caption :

Potent hepatitis C virus (HCV) NS3 protease inihibitor

extended description :

Potent hepatitis C virus (HCV) NS3 protease inihibitor

chemical name text :

1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1R,2S)-2-vinylcyclopropane-1-carboxamide

formula :

C35H46ClN5O9S

formula text :

C35H46ClN5O9S

cas num :

630420-16-5

USD :

260 USD

product details :

Potent hepatitis C virus (HCV) NS3 protease inihibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage