7741/10 | Tocris Bioscience 7741/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7741/10

catalog :

7741/10

quantity :

10 mg (also 50 mg)

price :

176 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7741 - STING agonist C53 C25H19ClF4N2O2 CAS No. 2259624-71-8

product information

master code :

7741

SKU :

7741/10

product name :

STING agonist C53

unit size :

10 mg (also 50 mg)

description :

Pan-polymorph STING agonist

target :

STING Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

490.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

STING agonist C53 is an activator of human STING (EC50 = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

top caption :

Pan-polymorph STING agonist

extended description :

Pan-polymorph STING agonist

chemical name text :

1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide

formula :

C25H19ClF4N2O2

formula text :

C25H19ClF4N2O2

cas num :

2259624-71-8

USD :

176 USD

product details :

Pan-polymorph STING agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage