7730/10 | Tocris Bioscience 7730/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7730/10

catalog :

7730/10

quantity :

10 mg

price :

262 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7730 - AS2717638 C25H25N3O5 CAS No. 2148339-28-8

product information

master code :

7730

SKU :

7730/10

product name :

AS2717638

unit size :

10 mg

description :

Selective, brain penetrant LPA5 antagonist

target :

LPAR5/LPA5/GPR92

category :

Small Molecules

purity :

98%

observed molecular weight :

447.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AS2717638 is a potent LPA5 receptor antagonist (IC50 = 38 nM in BV-2 microglia cells). It is selective for LPA5 over LPA1, LPA2, and LPA3. It inhibits LPA-mediated pro-inflammatory transcription factor phosphorylation. In vivo , AS2717638 inhibits LPA5 agonist-induced allodynia in mice. It also exhibits analgesic effects against both neuropathic and inflammatory pain in rodent models. Orally bioavailable and brain penetrant.

top caption :

Selective, brain penetrant LPA5 antagonist

extended description :

Selective, brain penetrant LPA5 antagonist

chemical name text :

6,7-Dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone

formula :

C25H25N3O5

formula text :

C25H25N3O5

cas num :

2148339-28-8

USD :

262 USD

product details :

Selective, brain penetrant LPA5 antagonist

alt names :

G protein-coupled receptor 92, GPR92, GPR92G-protein coupled receptor 92, GPR93, GPR93G-protein coupled receptor 93, KPG_010, LPA receptor 5, LPA5, LPA5LPA-5, lysophosphatidic acid receptor 5

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage