7727/2 | Tocris Bioscience 7727/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7727/2

catalog :

7727/2

quantity :

2 mg

price :

405 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective JAK2/3 Degrader (PROTAC )

product information

master code :

7727

SKU :

7727/2

product name :

SJ 10542

unit size :

2 mg

description :

Potent and selective JAK2/3 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

97%

observed molecular weight :

818.96

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC ) (DC50 values are 11 nM and 14 nM; Dmax = 92% and 90% for JAK3 and JAK2, respectively); uses a phenyl glutarimide ligand as the cereblon recruiter. Degrades JAK2 in ex vivo cell lines and patient derived xenografts (DC50= 120 nM) and displays high selectivity over GSPT1 and other members of the JAK family. . JAK3 antibody validated for Western Blot also available: Catalog # MAB4699 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent and selective JAK2/3 Degrader (PROTAC )

extended description :

Potent and selective JAK2/3 Degrader (PROTAC )

chemical name text :

4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide

formula :

C41H46N12O5S

formula text :

C41H46N12O5S

cas num :

2789678-92-6

USD :

405 USD

product details :

Potent and selective JAK2/3 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage