7721/2 | Tocris Bioscience 7721/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7721/2

catalog :

7721/2

quantity :

2 mg

price :

231 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective LCK Degrader (PROTAC )

product information

master code :

7721

SKU :

7721/2

product name :

SJ 11646

unit size :

2 mg

description :

Potent and selective LCK Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

746.28

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJ 11646 is a potent LCK (lymphocyte-specific protein tyrosine kinase) Degrader (PROTAC DC50 = 0.00838 pM). It comprises Dasatinib (Cat. No. 6793), as the LCK ligand, and a phenyl glutarimide-based cereblon binder. It shows cytotoxicity in LCK-activated T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary leukemia samples in vitro . In vivo , SJ11646 shows anti-leukemic efficacy in patient-derived xenograft models of T-ALL. . LCK antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3704 and MAB37041 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent and selective LCK Degrader (PROTAC )

extended description :

Potent and selective LCK Degrader (PROTAC )

chemical name text :

N-(2-Chloro-6-methylphenyl)-2-((6-(4-(3-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)propyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

formula :

C36H40ClN9O5S

formula text :

C36H40ClN9O5S

cas num :

2933135-82-9

USD :

231 USD

product details :

Potent and selective LCK Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage