7720/10 | Tocris Bioscience 7720/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7720/10

catalog :

7720/10

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7720 - SJ 6986 C20H14F3N3O7S CAS No. 2765625-93-0

product information

master code :

7720

SKU :

7720/10

product name :

SJ 6986

unit size :

10 mg (also 50 mg)

description :

Molecular glue; induces degradation of GSPT1/2

target :

Molecular Glues

category :

Small Molecules

purity :

98%

observed molecular weight :

497.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo , SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.

top caption :

Molecular glue; induces degradation of GSPT1/2

extended description :

Molecular glue; induces degradation of GSPT1/2

chemical name text :

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide

formula :

C20H14F3N3O7S

formula text :

C20H14F3N3O7S

cas num :

2765625-93-0

USD :

212 USD

product details :

Molecular glue; induces degradation of GSPT1/2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage