7719/10 | Tocris Bioscience 7719/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7719/10

catalog :

7719/10

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

MTHFD2 inhibitor

product information

master code :

7719

SKU :

7719/10

product name :

TH 9619 disodium salt

unit size :

10 mg (also 50 mg)

description :

MTHFD2 inhibitor

target :

Dehydrogenase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

495.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro , It shows antiproliferative efficacy in acute myeloid leukemia (AML) cells and T-ALL Jurkat cells. In vivo , TH9619 disodium salt impairs cancer progression in a mouse disease model of AML.

top caption :

MTHFD2 inhibitor

extended description :

MTHFD2 inhibitor

chemical name text :

Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate

formula :

C17H16FN7Na2O7

formula text :

C17H16FN7Na2O7

USD :

159 USD

product details :

MTHFD2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage