7715/10 | Tocris Bioscience 7715/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7715/10

catalog :

7715/10

quantity :

10 mg (also 50 mg)

price :

287 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

C25-140 CAS No. 1358099-18-9 TRAF6-Ubc13 interaction inhibitor

product information

master code :

7715

SKU :

7715/10

product name :

C25-140

unit size :

10 mg (also 50 mg)

description :

TRAF6-Ubc13 interaction inhibitor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

457.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

C25-140 binds directly to TNF receptor-associated factor 6 (TRAF6) and inhibits its interaction with ubiquitin-conjugating enzyme Ubc13. C25-140 reduces TRAF6-Ubc13 activity and decreases NF- B activation and inflammatory signaling in vitro . C25-140 exhibits selectivity for TRAF6 over other E3 ligases except cIAP1. In in vivo mouse models of autoimmune psoriasis and rheumatoid arthritis, the compound improves disease symptoms. The compound also suppresses the pro-inflammatory signaling activity of IL-17A and prevents its inhibitory effect on the anti-HBV action of IFN- HepG2 cells.

top caption :

TRAF6-Ubc13 interaction inhibitor

extended description :

TRAF6-Ubc13 interaction inhibitor

chemical name text :

3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone

formula :

C26H31N7O

formula text :

C26H31N7O

cas num :

1358099-18-9

USD :

287 USD

product details :

TRAF6-Ubc13 interaction inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage