7713/10 | Tocris Bioscience 7713/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7713/10

catalog :

7713/10

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7713 - AMG 510 C30H30F2N6O3 CAS No. 2252403-56-6

product information

master code :

7713

SKU :

7713/10

product name :

AMG 510

unit size :

10 mg (also 50 mg)

description :

Potent and selective KRASG12C inhibitor

target :

Ras GTPase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

560.6

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.

top caption :

Potent and selective KRASG12C inhibitor

extended description :

Potent and selective KRASG12C inhibitor

chemical name text :

(1R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one

formula :

C30H30F2N6O3

formula text :

C30H30F2N6O3

cas num :

2252403-56-6

USD :

190 USD

product details :

Potent and selective KRASG12C inhibitor

alt names :

Sotorasib

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage