7709/10 | Tocris Bioscience 7709/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7709/10

catalog :

7709/10

quantity :

10 mg (also 50 mg)

price :

128 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7709 - Trametinib C26H23FIN5O4 CAS No. 871700-17-3

product information

master code :

7709

SKU :

7709/10

product name :

Trametinib

unit size :

10 mg (also 50 mg)

description :

Potent and selective MEK inhibitor; orally bioavailable

target :

MEK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

615.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Trametinib is a potent and selective MEK1 and MEK2 inhibitor (IC50 = 0.92 and 1.8 nM, respectively, in cell-free assays). In vitro , it inhibits the growth of human colorectal cancer cell lines expressing either B-RAF or K-RAF (IC50 values range from 0.48 to 36 nM). In vivo , it suppresses tumor growth of HT-29 and COLO205 xenografts in nude mice. Trametinib induces apoptosis. This compound is orally bioavailable.

top caption :

Potent and selective MEK inhibitor; orally bioavailable

extended description :

Potent and selective MEK inhibitor; orally bioavailable

chemical name text :

N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide

formula :

C26H23FIN5O4

formula text :

C26H23FIN5O4

cas num :

871700-17-3

USD :

128 USD

product details :

Potent and selective MEK inhibitor; orally bioavailable

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage