chemical

7705/10

7705/10

10 mg (also 50 mg)

116 USD

7705/10

Masitinib

10 mg (also 50 mg)

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

CD117/c-kit

Small Molecules

98%

498.64

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

Masitinib is a potent inhibitor of the tyrosine kinase receptor colony-stimulating factor 1R (CSF-1R) (IC50 = 90 nM). It is also an NLRP3 inflammasome activator. Masitinib additionally inhibits the proteolytic activity of SARS-CoV-2 main protease (Mpro) and blocks viral replication, as well as acting as a PDGFR / inhibitor. In vivo , Masitinib ameliorates cognitive impairment in transgenic mice model of Alzheimer s disease, and slows disease progression in a rat model of amyotrophic lateral sclerosis (ALS). Orally bioavailable.

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide

C28H30N6OS

C28H30N6OS

790299-79-5

116 USD

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

AGTAVPRL, AII, CD117, CD117 antigen, CD140a, CD140b, CIAS1, ckit, c-kit, Cryopyrin, EC 2.7.10, EC 2.7.10.1, FCAS, FCU, KIT, Main Protease, Mpro, MWS, NACHT, NALP3, PBT, PDGFR alpha, PDGFRA, PDGFRB, piebald trait, Proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, PYPAF1, SCF R, SCFR, SCFRmast/stem cell growth factor receptor, soluble KIT variant 1, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Store at -20░C