7701/5 | Tocris Bioscience 7701/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7701/5

catalog :

7701/5

quantity :

5 mg

price :

295 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7701 - RAGE 229 C23H22N4O2 CAS No. 2143072-85-7

product information

master code :

7701

SKU :

7701/5

product name :

RAGE 229

unit size :

5 mg

description :

ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice

target :

RAGE/AGER

category :

Small Molecules

purity :

98%

observed molecular weight :

386.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RAGE 229 is an antagonist of the interaction between the cytoplasmic tail of the receptor for advanced glycation end products (ctRAGE) and the formin, Diaphanous-1 (DIAPH1) (KD for binding to ctRAGE = 2 nM). RAGE 229 inhibits the migration of human aortic smooth muscle cells in an in vitro wound healing assay (IC50 = 120 nM). RAGE 229 reduces short- and long-term complications of diabetes in mouse models, without lowering blood glucose concentrations. RAGE 229 also reduces plasma concentrations of TNF- , IL-6, and CCL2/JE-MCP1 and attenuates inflammatory signaling in diabetic mice.

top caption :

ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice

extended description :

ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice

chemical name text :

N-[4-[7-Cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]acetamide

formula :

C23H22N4O2

formula text :

C23H22N4O2

cas num :

2143072-85-7

USD :

295 USD

product details :

ctRAGE-DIAPH1 interaction antagonist; reduces inflammatory signaling in diabetic mice

alt names :

advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage