7682/5 | Tocris Bioscience 7682/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7682/5

catalog :

7682/5

quantity :

5 mg

price :

465 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7682 - JQAD1 C48H52F4N6O9 CAS No. 2417097-18-6

product information

master code :

7682

SKU :

7682/5

product name :

JQAD1

unit size :

5 mg

description :

Potent and selective EP300 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

932.97

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JQAD1 is a potent and selective histone acetyltransferase EP300 Degrader (PROTAC DC50 31.6 nM); comprises an EP300 inhibitor, A485 (Cat. No. 6387), joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis. JQAD1 suppresses tumor growth in NSG mice xenografted with Kelly cells. CRC and MYCN genes are downregulated in tumors treated with JQAD1. JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation. . p300 antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3789 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent and selective EP300 Degrader

extended description :

Potent and selective EP300 Degrader (PROTAC )

chemical name text :

12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3 -(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2 ,4 -dioxo-2,3-dihydrospiro[indene-1,5 -oxazolidin]-5-yl)dodecanamide

formula :

C48H52F4N6O9

formula text :

C48H52F4N6O9

cas num :

2417097-18-6

USD :

465 USD

product details :

Potent and selective EP300 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage