7676/5 | Tocris Bioscience 7676/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7676/5

catalog :

7676/5

quantity :

5 mg

price :

291 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7676 - JQKD 82 dihydrochloride C27H40N4O5.2HCl

product information

master code :

7676

SKU :

7676/5

product name :

JQKD 82 dihydrochloride

unit size :

5 mg

description :

Selective inhibitor of lysine demethylase 5

target :

Histone Demethylase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

573.56

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JQKD 82 dihydrochloride is cell-permeable, selective inhibitor of lysine demethylase 5 (KDM5). JQKD 82 does not show activity toward other KDMs; and it has selectivity for KDM5A over other KDM5 isoforms. JQKD 82 causes hypermethylation of H3K4me3, downregulation of MYC targets and RNAPII phosphorylation; it suppresses multiple myeloma cell (MM.1S) growth (IC50 = 0.42 umol/L). JQKD 82-treated tumors display an increase in H3K4me3 levels and results in a reduction of MYC immuno-staining in NSG mice.

top caption :

Selective inhibitor of lysine demethylase 5

extended description :

Selective inhibitor of lysine demethylase 5

chemical name text :

2,4-Diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate dihydrochloride

formula :

C27H40N4O5.2HCl

formula text :

C27H40N4O5.2HCl

cas num :

2863635-05-4

USD :

291 USD

product details :

Selective inhibitor of lysine demethylase 5

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage