7675/2 | Tocris Bioscience 7675/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7675/2

catalog :

7675/2

quantity :

2 mg

price :

231 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7675 - SJ 1008030 C42H43N13O7S.CF3CO2H

product information

master code :

7675

SKU :

7675/2

product name :

SJ 1008030

unit size :

2 mg

description :

Selective JAK2 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

987.97

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJ 1008030 is a potent and selective JAK2 Degrader (PROTAC ). This compound shows potent antileukemic efficacy in CRLF2r ALL (Acute Lymphoblastic Leukemia) cell lines (EC50 = 5.4 nM). SJ 1008030 induces dose-dependent JAK2 degradation (IC50 = 32 nM) in xenograft models of kinase-driven ALL, with no effect on GSPT1 levels. . JAK2 antibodies validated for Western Blot also available: Catalog # NBP2-59451 and AF2988 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Selective JAK2 Degrader (PROTAC )

extended description :

Selective JAK2 Degrader (PROTAC )

chemical name text :

4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate

formula :

C42H43N13O7S.CF3CO2H

formula text :

C42H43N13O7S.CF3CO2H

cas num :

2863634-97-1

USD :

231 USD

product details :

Selective JAK2 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage