7663/10 | Tocris Bioscience 7663/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7663/10

catalog :

7663/10

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7663 - Ozanimod C23H24N4O3 CAS No. 1306760-87-1

product information

master code :

7663

SKU :

7663/10

product name :

Ozanimod

unit size :

10 mg (also 50 mg)

description :

Potent and selective S1P1 and S1P5 agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

404.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTP S assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro , Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo , Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.

top caption :

Potent and selective S1P1 and S1P5 agonist

extended description :

Potent and selective S1P1 and S1P5 agonist

chemical name text :

5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile

formula :

C23H24N4O3

formula text :

C23H24N4O3

cas num :

1306760-87-1

USD :

159 USD

product details :

Potent and selective S1P1 and S1P5 agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage