7652/10 | Tocris Bioscience 7652/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7652/10

catalog :

7652/10

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Meier A, Zawada D, De Angelis M, Martens L, Santamaria G, Zengerle S, et al. Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease. Nat Biotechnol. 2023;: pubmed publisher

image

image 1 :

Cat.No. 7652 - Linsitinib C26H23N5O CAS No. 867160-71-2

product information

master code :

7652

SKU :

7652/10

product name :

Linsitinib

unit size :

10 mg (also 50 mg)

description :

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

target :

IGF-I R/IGF1R

category :

Small Molecules

purity :

98%

observed molecular weight :

421.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Linsitinib is a potent and selective dual inhibitor of the IGF-1 receptor (IC50 = 35 nM) and insulin receptor (IC50 = 75 nM); it inhibits ligand-dependent auto-phosphorylation of both receptor tyrosine kinases and prevents ligand-induced activation of downstream pathways including pAKT, pERK1/2 and p-p70S6K. The compound is selective for IGF-1R, IR and IRR in a panel of 88 kinases. Lisintinib inhibits proliferation in a variety of tumor cell lines and shows robust in vivo antitumor efficacy in an IGF-1R-driven LSN xenograft model. Orally bioavailable.

top caption :

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

extended description :

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

chemical name text :

cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol

formula :

C26H23N5O

formula text :

C26H23N5O

cas num :

867160-71-2

USD :

227 USD

product details :

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage