7645/10 | Tocris Bioscience 7645/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7645/10

catalog :

7645/10

quantity :

10 mg

price :

343 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent SMARCA2/4 inhibitor

product information

master code :

7645

SKU :

7645/10

product name :

FHT 2344

unit size :

10 mg

description :

Potent SMARCA2/4 inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

528.6

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC50 values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC50 values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.

top caption :

Potent SMARCA2/4 inhibitor

extended description :

Potent SMARCA2/4 inhibitor

chemical name text :

N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide

formula :

C23H24N6O5S2

formula text :

C23H24N6O5S2

cas num :

2468058-90-2

USD :

343 USD

product details :

Potent SMARCA2/4 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage