7644/2 | Tocris Bioscience 7644/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7644/2

catalog :

7644/2

quantity :

2 mg

price :

282 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

FHT 1015 CAS No. 2368903-18-6 Potent and selective inhibitor for SMARCA4/2 ATPase of the SWI/SNF complex

product information

master code :

7644

SKU :

7644/2

product name :

FHT 1015

unit size :

2 mg

description :

Potent and selective SMARCA4/2 inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

555.69

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FHT 1015 is a potent and selective allosteric inhibitor of SMARCA4/SMARCA2 ATPase (also known as BRG1/BRM respectively) of the BAF (BRG/Brahma-associated factors) complex, with IC50s of 10 nM. Exhibits selectivity for SMARCA4/SMARCA2 over related CHD4 (IC50 of 400 M). Mutations in I1143 on SMARCA4 and I1173 on SMARCA2 render these proteins resistant to inhibition by FHT 1015. The compound induces lineage-specific changes in chromatin accessibility in different cancer cell lines, preventing binding of cancer-associated transcription factors, SOX10 and MITF transcription factors.

top caption :

Potent and selective SMARCA4/2 inhibitor

extended description :

Potent and selective SMARCA4/2 inhibitor

chemical name text :

(S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide

formula :

C25H25N5O4S3

formula text :

C25H25N5O4S3

cas num :

2368903-18-6

USD :

282 USD

product details :

Potent and selective SMARCA4/2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage