7640/10 | Tocris Bioscience 7640/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7640/10

catalog :

7640/10

quantity :

10 mg (also 50 mg)

price :

181 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7640 - Tucatinib C26H24N8O2 CAS No. 937263-43-9

product information

master code :

7640

SKU :

7640/10

product name :

Tucatinib

unit size :

10 mg (also 50 mg)

description :

Potent and selective ErbB2 inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

480.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Tucatinib is a potent and selective ErbB-2 (also called HER2) kinase inhibitor (IC50 = 7 nM). It exhibits 50-fold selectivity for ErbB-2 over EGFR. In vitro , Tucatinib inhibits ErbB-2 signaling activity and cell proliferation in ErbB-2-amplified breast cancer cell lines (BT-474). In vivo , Tucatinib (25-100 mg/kg) reduces tumor volume in breast and gastric xenograft mouse models.This compound is orally bioavailable.

top caption :

Potent and selective ErbB2 inhibitor

extended description :

Potent and selective ErbB2 inhibitor

chemical name text :

N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine

formula :

C26H24N8O2

formula text :

C26H24N8O2

cas num :

937263-43-9

USD :

181 USD

product details :

Potent and selective ErbB2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage