7637/10 | Tocris Bioscience 7637/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7637/10

catalog :

7637/10

quantity :

10 mg

price :

308 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective TNNI3K inhibitor, orally bioavailable

product information

master code :

7637

SKU :

7637/10

product name :

GSK 329

unit size :

10 mg

description :

Potent and selective TNNI3K inhibitor, orally bioavailable

target :

MAPK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

472.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 329 is a potent and selective TNNI3K (cardiac troponin I-interacting kinase) inhibitor (IC50 = 10 nM). It exhibits selectivity for TNNI3K over human VEGFR2 (40-fold), p38 (80-fold), B-Raf ( 200-fold) and displays 100-fold selectivity over 80% of 185 kinases tested. In vivo , GSK 329 reduces infarct size, ROS levels, and p38 activation in a mouse model of ischemia/reperfusion cardiac injury. This compound is orally bioavailable.

top caption :

Potent and selective TNNI3K inhibitor, orally bioavailable

extended description :

Potent and selective TNNI3K inhibitor, orally bioavailable

chemical name text :

N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N -[3-(trifluoromethyl)phenyl]urea

formula :

C19H14Cl2F3N5O2

formula text :

C19H14Cl2F3N5O2

cas num :

1268490-12-5

USD :

308 USD

product details :

Potent and selective TNNI3K inhibitor, orally bioavailable

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage