7636/10 | Tocris Bioscience 7636/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7636/10

catalog :

7636/10

quantity :

10 mg (also 50 mg)

price :

162 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7636 - AS 1517499 C20H20ClN5O2 CAS No. 919486-40-1

product information

master code :

7636

SKU :

7636/10

product name :

AS 1517499

unit size :

10 mg (also 50 mg)

description :

STAT6 inhibitor

target :

STAT6

category :

Small Molecules

purity :

98%

observed molecular weight :

397.86

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro , it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.

top caption :

STAT6 inhibitor

extended description :

STAT6 inhibitor

chemical name text :

2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide

formula :

C20H20ClN5O2

formula text :

C20H20ClN5O2

cas num :

919486-40-1

USD :

162 USD

product details :

STAT6 inhibitor

alt names :

BCDF, BCGF1, BCGF-1, BSF1, BSF-1, D12S1644, EC 2.4.1.227, EC 2.7.7.6, IL3, IL4, IL-4 Stat, IL4E12, IL-4-STAT, MCGF, MULTI-CSF, signal transducer and activator of transcription 6, signal transducer and activator of transcription 6, interleukin-4 induced, STAT, interleukin-4 induced, STAT, interleukin4-induced, STAT6B, STAT6C, transcription factor IL-4 STAT

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage