product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
AS 1517499
catalog :
7636/10
quantity :
10 mg (also 50 mg)
price :
162 USD
more info or order :
Tocris Bioscience product webpage
image
image 1 :
Tocris Bioscience 7636/10 image 1
Cat.No. 7636 - AS 1517499 C20H20ClN5O2 CAS No. 919486-40-1
product information
brand :
Tocris
catalog number base :
7636
SKU :
7636/10
product name :
AS 1517499
units size :
10 mg (also 50 mg)
description :
STAT6 inhibitor
target :
STAT Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
397.86
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AS 1517499 is a potent STAT6 inhibitor (IC50 = 21 nM). In vitro , it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.
top caption :
STAT6 inhibitor
extended description :
STAT6 inhibitor
chemical name text :
2-[[2-(3-Chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide
formula :
C20H20ClN5O2
formula text :
C20H20ClN5O2
cas num :
919486-40-1
USD :
162 USD
product details :
STAT6 inhibitor
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK