7631/10 | Tocris Bioscience 7631/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7631/10

catalog :

7631/10

quantity :

10 mg (also 50 mg)

price :

74 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7631 - Idelalisib C22H18FN7O CAS No. 870281-82-6

product information

master code :

7631

SKU :

7631/10

product name :

Idelalisib

unit size :

10 mg (also 50 mg)

description :

Potent PI 3-Kinase isoform inhibitor

target :

PI 3-Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

415.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Idelalisib is a potent PI 3-Kinase inhibitor (IC50 = 2.5 nM for p110 it exhibits 40-fold selectivity for the isoform over other PI 3-K class I enzymes (IC50s = 89, 565, and 820 nM for p110 , p110 , and p110 respectively). Idelalisib blocks constitutive PI 3-K signaling in malignant B-cell lines and primary patient tumor cells. Idelalisib inhibits chronic lymphocytic leukemia cell chemotaxis and downregulates chemokine secretion triggered by B-cell receptor signaling in stromal cocultures. Idelalisib lacks significant cytotoxicity toward natural killer (NK) cells. Idelalisib also decreases production of inflammatory cytokines, including TNF- , CD40L, and IL-6 by T cells and IFN- by NK cells. Idelalisib is cell-permeable and orally bioavailable.

top caption :

Potent PI 3-Kinase isoform inhibitor

extended description :

Potent PI 3-Kinase isoform inhibitor

chemical name text :

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

formula :

C22H18FN7O

formula text :

C22H18FN7O

cas num :

870281-82-6

USD :

74 USD

product details :

Potent PI 3-Kinase isoform inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage