7630/10 | Tocris Bioscience 7630/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7630/10

catalog :

7630/10

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7630 - Pridopidine C15H23NO2S CAS No. 346688-38-8

product information

master code :

7630

SKU :

7630/10

product name :

Pridopidine

unit size :

10 mg (also 50 mg)

description :

Highly selective 1 agonist

target :

Sigma1 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

281.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pridopidine is a selective high affinity -1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ~30-fold and ~100-fold selectivity over the dopamine D3 receptor and the D2 receptor, respectively. Pridopidine is a low affinity dopamine D2 receptor antagonist (Ki (low) = 17.5 Ki (high) = 7.5 M). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington s disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo . Orally bioavailable.

top caption :

Highly selective 1 agonist

extended description :

Highly selective 1 agonist

chemical name text :

4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine

formula :

C15H23NO2S

formula text :

C15H23NO2S

cas num :

346688-38-8

USD :

173 USD

product details :

Highly selective 1 agonist

alt names :

PL-101,ACR16,Huntexil

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage